The Multidimensional Brain
The Paris-Saclay Institute of Neuroscience (Neuro-PSI) is dedicated to basic Neuroscience, at all scales of analysis, from molecule to cognition and from embryo to adult. It is a joint Research Unit of the CNRS and Paris-Sud University (UMR9197), currently located in Gif-sur-Yvette and Orsay, 25km South to Paris. It forms, with its sister Institute NeuroSpin (CEA Saclay), the NeuroSaclay Center promoting Neuroscience at the highest international standards within the Paris-Saclay University.



Cortical mechanisms of auditory-visual interactions

The perception of the environment generally involves several sensory modalities at once, and as Rimbaud noted in the famous text of Les Correspondances, "perfumes, colors and sounds answer each other" in our brain. Thus it is easier in a noisy environment to follow one’s interlocutor if one can also read on its lips.
But if this type of phenomenon is a well-established psychological observation, the neural mechanisms that allow us to combine the information of several senses in our perception are still very poorly understood.

In an article published on May 22, 2019 by Elife, the team of Brice Bathellier , has demonstrated that in the mouse, the connections that, at the level of the cortex, bind the auditory system to the visual system act on the processing of visual information in a way that depends on the visual context.


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A key point of learning theory demonstrated through optogenetics

The brain learns constantly to improve our actions according to our experiences. Several theories aim to account for this fundamental property, one of the most popular being reinforcement learning, also used in artificial intelligence. This theory postulates that learning emerges through a specific reinforcement of connections between neurons that are active during an event, an action, or a sequence of events and actions leading to a reward. One of the key points of this theory is that the more active involved neurons are, the faster and more solid the reinforcement of connection is. Thus the events that most strongly activate our brain should be learned in priority with respect to other events.


In order to demonstrate that this principle actually guides biological learning, the team of Brice Bathellier used two optical methods to read and modify the activity of large sets of genetically defined neurons (optogenetics).
The details of this study can be found in an article published in the journal Nature Communications in 2019, April 1st.


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Scientific conferences

Neuro-PSI Conference on September 20th

On Friday, september 20th at 11:00, Sophie Aimon from the Technical University of Munich, Germany, will give a talk on this following topic
« Ultra-fast whole–brain imaging in behaving flies »

Invited by François Rouyer

- See the pdf



Scientific Themes

S. Creuzet Development-Evolution dept.

F. Rouyer Molecules-Circuits dept.

JM Édeline Cognition-Behavior dept.

P. Affaticati / A. Jenett Development-Evolution dept.

D. Shulz UNIC

A. Veyrac / S. Laroche Cognition-Behavior dept.

C. Huetz / JM Édeline Cognition-Behavior dept.

D. Vasiliauskas Molecules-Circuits dept.

M. Perron Development-Evolution dept.

S. Rétaux Development-Evolution dept.

J. Wu / G. Fortin Molecules-Circuits dept.

J. Fournier / Y. Frégnac ICN dept.


Available jobs

M1 and M2 internships available

To investigate the genetic basis of individuality and maintenance of neuronal functionality.
Contact Daniel Vasiliauskas


How is sensory information transformed into appropriate motor output ?

PhD student

Thesis Projects in 2019

BioSigne and SDSV Thesis Projects

Post-doc position for 2019

New team : Neural Circuits & Behavior

M2 internships available

New team : Neural circuits & Behavior


The Sleeping Brain

The Institut du Fer à Moulin (IFM) symposium co-organized with Neuroscience Paris Seine (NPS), 2019, October 4









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