Le cerveau multidimensionnel

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Neurobiologie intégrative du cerveau postérieur

Responsable : Gilles Fortin

The intrinsic logic of neural networks controlling defined circuit functions and behaviours in the central nervous system is a fundamental issue of neuroscience. We study the central control of breathing, a classical model system to i) perform integrative neurobiology and ii) extend the significance of developmental biology, beyond anatomical organization to the level of network assembly and function.

We identified in the mouse embryo, the progenitor domains that give rise to distinct components of the respiratory network. We are currently using developmental genetics tools, eletrophysiology and anatomical viral tracings to fate map, follow the migration, trace the connectivity, and invalidate and activate selective neuronal populations in the circuit and thus provide constituent cells with molecular identities and reveal pre-disposition to dysfunctions. Click here if you want to know more.

Calcium-imaging of the neuronal activity of the main respiratory center
Patch-clamp recording of neuronal activity of a respiratory neuron
Fluorescent labeling of neuronal connectivity using Rabies viruses


- September 2017

Read our latest publication in Nature Communications Website

Wu J, Capelli P, Bouvier J, Goulding M, Arber S, Fortin G A V0 core neuronal circuit for inspiration.
Nat Commun. 2017 Sep 15 ;8(1):544. doi : 10.1038/s41467-017-00589-2.






- July 2017

New publication in PNAS

Hernandez-Miranda LR, Ruffault PL, Bouvier J, Murray AJ, Morin-Surun MP, Zampieri N, Cholewa-Waclaw JB, Ey E, Brunet JF, Champagnat J, Fortin G, Birchmeier, C.
Genetic identification of a hindbrain nucleus essential for innate vocalization.
Proc. Natl. Acad. Sci U.S.A. 2017 Jul 25 ;114(30):8095-8100





- July 2015

Read our new publication on PNAS website.

Guerrier C, Hayes JA, Fortin G, Holcman D (2015).
Robust network oscillations during mammalian respiratory rhythm generation driven by synaptic dynamics.
PNAS. 2015 Jul 20. pii : 201421997.






- April 2015

New publication, read it on eLife website.

Using a genetic fate-mapping strategy in mice, we provided the characteristic molecular signature of a small group of brainstem respiratory neurons, the RTN. We combined this genetic accessibility to functional recordings in vitro to demonstrate that the RTN is an essential module for carbon dioxyde responsiveness of the respiratory network.

Dernière mise à jour : 25/09/2017

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