Le cerveau multidimensionnel

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Oscillatory and stochastic dynamics in thalamo-cortical networks

The laboratory of Alain Destexhe is specialized in computational neuroscience and theoretical neuroscience. The research themes are the modeling of the integrative properties of neurons and networks of cerebral cortex during "active" states (such as wakefulness), the role of noise on information processing of single neurons or networks of neurons, macroscopic aspects such as local field potentials and the collective dynamics at large scales, as well as the rhythmic properties of thalamic and cortical networks during sleep and epilepsy. The laboratory also participates to dynamic-clamp experiments (in collaboration with Bal’s lab at UNIC), where computational models directly interact with living neurons. The laboratory also participates to the conception of methods to analyze experimental data in vivo (intracellular, optical imaging), or to record in high-resolution (AEC metthod), in collaboration with several laboratories across Europe and North-America. This research is supported by grants from different institutions, such as the ANR (Agence Nationale de la Recherche), the EC (European Commission), the MRC (Medical Research Council of Canada), the NIH (National Institutes of Health, USA), and the HFSP (Human Frontier Science Program).

Techniques used

Computational modeling and numerical simulations of neurons and neural networks, Theoretical calculus,
Dynamic-clamp experiments, Conductance analysis from intracellular recordings, Morphological reconstruction with optical microscopy (Neurolucida)

For more details

For further information, see the laboratory’s web site cnrs.iaf.fr, or click on the icons below :












Selected Publications

- Jakob Wolfart, Damien Debay, Gwendal Le Masson, Alain Destexhe and Thierry Bal, Synaptic background activity controls spike transfer from thalamus to cortex, Nat Neurosci 8 : 1760-7, (2005) [pdf] [abstract]

- Luc Estebanez, Sami El Boustani, Alain Destexhe and Daniel Shulz, Correlated input reveals coexisting coding schemes in a sensory cortex, Nature Neuroscience 15 No12 : 1691-1699, (2012) [pdf]

- Alain Destexhe and Diego Contreras, Neuronal computations with stochastic network states, Science 314 : 85-90, (2006) [pdf] [abstract]

- Lyle Muller, Alexandre Reynaud, Frédéric Chavane and Alain Destexhe, The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave, Nature Communications 5 : 3675, (2014) [pdf] [abstract] [PubMed]

- Alain Destexhe, Stuart W. Hughes, Michelle Rudolph and Vincenzo Crunelli, Are corticothalamic ’up’ states fragments of wakefulness, Trends Neurosci 30 : 334-42, (2007) [pdf] [abstract]


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