Le cerveau multidimensionnel

Luc Estebanez

 

Integrative and Computational Neuroscience department (ICN)
Paris-Saclay Neuroscience Institute (Neuro-PSI)
UMR 9197 / CNRS - Paris-Sud University
Bâtiment 32, CNRS avenue de la Terrasse 91198 Gif-Sur-Yvette Cedex, FRANCE

 


- Tel : +33(0) 1 69 82 34 46
- Email : luc.estebanez [at] cnrs.fr
- Curriculum Vitae
- Google Scholar

 

How is sensori-motor integration carried in the brain ? How can complex sensory scenes get processed into multi-dimensional motor commands ?

To address these questions, we have developed - together with PhD students Aamir Abbasi, Dorian Goueytes and Henri Goueytes - a brain machine interface in the head-fixed mouse. It combines a readout of spiking activity in the whisker primary motor cortex and a direct feedback to the primary whisker cortex based on a patterned optogenetical feedback.

The chronic interfacing between brain and a artificial device is an important technological challenge, in particular in order to support many patients with motor deficits. It also provides a novel way to study the sensory-motor integration (Figure 3A). It combines a direct readout of motor spiking in the primary motor cortex via extracellular chronic recordings, with mesoscopic , and by directly feeding information into the primary sensory cortex, the sensory-motor loop is to some extend limited to the network between these two primary cortices, and becomes a more tractable topic to study.

Based on this experimental setup, I am currently exploring how the spatio-temporal structure of sensory inputs directly impacts motor control, and what are the cortical mechanisms of this sensori-motor integration.

In addition, I am interested in the possibility of connecting our brain interface with a robotic arm. This could be particularly to study the impact of the somatosensory feedback on the appropriation of the robotic arm in the body plan.

 

Original research/Patents

2018
- Aamir Abassi, Dorian Goueytes, Daniel E. Shulz, Valérie Ego-Stengel, Luc Estebanez, A fast intracortical brain–machine interface with patterned optogenetic feedback. Journal of Neural Engineering 15(4). PDF

- Matias Goldin, Evan Harrell, Luc Estebanez, Daniel E. Shulz Spatio-temporal coding in the rat primary and secondary somatosensory cortical areas. Nature Communications 9(1). PDF

- Eugenia Vilarchao, Luc Estebanez, Daniel Shulz, Isabelle Férézou, A supra-barrel map for direction selectivity to global motion in the mouse somatosensory cortex. Cell Reports 22(13). PDF

2017
- Luc Estebanez, Diana Hoffmann, Birgit C. Voigt and James F A Poulet, Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching, Cell Reports 20 : 308-318. PDF

2016
- Luc Estebanez, Julien Bertherat, Daniel Shulz, Laurent Bourdieu and Jean François Léger, A radial map of multi-whisker correlation selectivity in the rat barrel cortex, Nat Commun. 21(7) : 13528. PDF

- Christiane Wetzel, Simone Pifferi, Cristina Picci, Caglar Gök, Diana Hoffmann, Kiran K Bali, André Lampe, Liudmila Lapatsina, Raluca Fleischer, Ewan St John Smith, Valérie Begay, Mirko Moroni, Luc Estebanez, Johannes Kühnemund, Jan Walcher, Edgar Specker, Martin Neuenschwander, Jens Peter von Kries, Volker Haucke, Rohini Kuner, James F A Poulet, Jan Schmoranzer, Kate Pool and Gary R Lewin, Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity, Nature Neuroscience 20 : 209–218. PDF

2015
- Luc Estebanez, Jens kremkow and James F A Poulet, Matching Cell Type to Function in Cortical Circuits, Nature Neuroscience 87 : 249-251. PDF

2014
- Jean Sébastien Jouhanneau, Leiron Ferrarese, Luc Estebanez, Nick J. Audette, Michael Brecht and Alison L. Barth, Cortical fosGFP Expression Reveals Broad Receptive Field Excitatory Neurons Targeted by POm, Neuron 84 : 1065–1078. PDF

2012
- Luc Estebanez, Sami El Boustani, Alain Destexhe and Daniel Shulz, Correlated input reveals coexisting coding schemes in a sensory cortex, Nature Neuroscience 15(12) : 1691-1699. PDF

2011
- Julie Le Cam, Luc Estebanez, Vincent Jacob and Daniel Shulz, Spatial structure of multi-whisker receptive fields in the barrel cortex is stimulus-dependent, Journal of Neurophysiology 106 : 968-998. PDF

2010
- Vincent Jacob, Luc Estebanez, Julie Le Cam, Jean Yves Tiercelin, Patrick Parra, Gérard Parésys and Daniel Shulz, The Matrix : a new tool for probing the whisker-to-barrel system with natural stimuli, J Neurosci Methods 189 : 65-74. PDF

- Vincent Jacob, Luc Estebanez, Julie Le Cam, Jean Yves Tiercelin, Patrick Parra, Gérard Parésys and Daniel Shulz, The Matrix : a new tool for probing the whisker-to-barrel system with natural stimuli, J Neurosci Methods 189 : 65-74. PDF

- Luc Estebanez, Jean-Yves Tiercelin, Vincent Jacob, Daniel E. Shulz, UNIC, CNRS, ENS Paris. Brevet international PCT/FR2010/000541, 2010. PDF

 

Review articles

2018
- Luc Estebanez, Isabelle Ferezou, Valerie Ego-Stengel and Daniel Shulz, Representation of tactile scenes in the rodent barrel cortex, Neuroscience 368 : 81-94. PDF

2017
- Luc Estebanez, Jens Kremkow, James Poulet, Matching Cell Type to Function in Cortical Circuits, Neuron 87 : 249-251. PDF

2014
- Luc Estebanez, Sami El Boustani, Alain Destexhe and Daniel Shulz, What the whiskers tell the tactile brain, Med Sci (Paris) 30(1) : 93-8. PDF

2012
- Francesca Anselmi, Julien Bertherat, Luc Estebanez, Marcel van‘t Hoff, Kathleen Zylbersztejn, An interdisciplinary learning experience in neuro-optics, Journal of Physiology-Paris, 106(3-4), 58-61. PDF


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