Le cerveau multidimensionnel

Isabelle Férézou

 

CONTACT

Isabelle Ferezou
UNIC Unit of Neuroscience, Information & Complexity
Paris-Saclay Institute of Neurosciences (Neuro-PSI)
UMR 9197 / CNRS - Université Paris-Sud
Building 32, CNRS avenue de la Terrasse 91198 Gif-Sur-Yvette Cedex, FRANCE

Tel : +33 (0) 169823402
Fax : +33 (0) 169823427

 

My research is centered on the study of the integrative properties of the cerebral cortex, with a particular focus on the processing of tactile sensory information. Using the mouse vibrissa system as a model, I study how complex tactile scenes are processed within the cortical network at the mesoscopic scale.

Using voltage sensitive dye imaging, eventually coupled with electrophysiology or optogenetics as needed, I seek to understand :

  • How the cortex extracts the global properties of the objects explored from complex multiwhisker sequences of tactile stimuli ?
  • How the cortical activation induced by tactile stimuli is modulated by the behavior of the animal ?
  • Is the somatosensory cortex able to generate waiting signals on the basis of the sensorimotor context ?

Previously ; I have achieved my PhD in 2003 at the ESPCI ParisTech while working with Dr. Bertrand Lambolez on cortical GABAergic interneurons. Using the single-cell RT-PCR technique in combination with patch-clamp recordings in acute cortical slices, I have demonstrated the specific synaptic activation of cortical VIP interneurons by afferent serotoninergic fibers via the ionotropic 5HT3 receptor. I then joined in 2004 the Laboratory of Sensory Processing directed by the Pr. Carl Petersen, at EPFL (Lausanne, Switzerland), where I have adapted the voltage sensitive dye imaging technique to study the cortical processing of sensory information in awake mice. This work revealed differential processing of sensory input depending upon behaviour. Moreover, it demonstrated that sensory processing in motor cortex may contribute significantly to active sensory perception. In 2007, I have integrated the Laboratory of Neurobiology of the ESPCI ParisTech, in the team “Physiologie des Interneurones” directed by Pr. Jean Rossier as a CNRS researcher fellow. There, my work was focused on the role of 5-HT3A expressing interneurons in the processing of sensory information. I finally joined the UNIC and the team "Sensory processing, neuromodulation and neural plasticity" directed by Daniel Shulz in 2011, attracted by the excellence of the multidisciplinary scientific environment, the expertise of the team in the field of tactile sensory processing, and the perspectives offered by the development of a unique multiwhisker stimulator.

 

Articles (19)

2017

- Luc Estebanez, Isabelle Ferezou, Valerie Ego-Stengel and Daniel Shulz, Representation of tactile scenes in the rodent barrel cortex, Neuroscience 368 : 81-94, (2017) [pdf]

- Isabelle Ferezou and Thomas Deneux, Review : How do spontaneous and sensory-evoked activities interact ?, Neurophotonics 4(3) : , (2017) [pdf] [PubMed]

2016

- Karine Thibault, Sebastien Rivière, Zsolt Lenkei, Isabelle Ferezou and Sophie Pezet, Orofacial Neuropathic Pain Leads to a Hyporesponsive Barrel Cortex with Enhanced Structural Synaptic Plasticity, PLoS One 22 ;11(8):e0160786 : , (2016)

- Hugot Raguet, Cyril Monier, Luc Foubert, Isabelle Ferezou, Yves Frégnac and Gabriel Peyré, Spatially Structured Sparse Morphological Component Separation for Voltage-Sensitive Dye Optical Imaging, Journal of Neuroscience Methods 257 : 76-96, (2016)

2015

- Lorraine Perronnet, Maria-Eugenia Vilarchao, Guillaume Hucher, Daniel Shulz, Gabriel Peyré and Isabelle Ferezou, An automated workflow for the anatomo-functional mapping of the barrel cortex, J Neurosci Methods : pii : S0165-0270(15)00341-6. doi : 10.1016/j.jneumet, (2015)

2014

- Caroline Magnain, Amandine Castel, Tanguy Boucneau, Manuel Simonutti, Isabelle Ferezou, Armelle Rancillac, Tania Vitalis, José Alain Sahel, Michel Paques and Michael Atlan, Holographic laser Doppler imaging of microvascular blood flow, J Opt Soc Am A Opt Image Sci Vis 31(12) : 2723-35, (2014)

- Yu Zhang, Audrey Bonnan, Guillaume Bony, Isabelle Ferezou, Susanna Pietropaolo, Melanie Ginger, Nathalie Sans, Jean Rossier, Ben Oostra, Gwendal Le Masson and Andreas Frick, Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice, Nat Neurosci. 17(12) : 1701-9, (2014)

2012

- Nicolas Narboux-Nême, Alexis Evrard, Isabelle Ferezou, Reha S. Erzurumlu, Pascal S Kaeser, Jeanne Lainé, Jean Rossier, Nicole Ropert, Thomas C. Südhof and Patricia Gaspar, Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex , J Neurosci. 32(18) : 6183-6196, (2012)

- Quentin Perrenoud, Jean Rossier, Isabelle Ferezou, Hélène Geoffroy, Thierry Gallopin, Tania Vitalis and Armelle Rancillac, Activation of cortical 5-HT(3) receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions, Front Neural Circuits 6 : 50, (2012)

2010

- Armelle Rancillac, Jeanne Lainé, Quentin Perrenoud, Hélène Geoffroy, Isabelle Ferezou, Tania Vitalis and Jean Rossier, Degenerative abnormalities in transgenic neocortical neuropeptide Y interneurons expressing tau-green fluorescent protein, J Neurosci Res 88(3) : 487-499, (2010)

- Ksenija Vucurovic, Thierry Gallopin, Isabelle Ferezou, Armelle Rancillac, Pascal Chameau, Hélène Geoffroy, Johannes A van Hooft, Hannah Monyer, Jean Rossier and Tania Vitalis, Serotonin 3A receptor subtype as an early and protracted marker of cortical interneuron subpopulations, Cereb. Cortex 20(10) : 2333-47, (2010)

2009

- Raphael Lebeuf, Isabelle Ferezou, Jean Rossier, Stellios Arseniyadis and Janine Cossy, Straightforward synthesis of the near-infrared fluorescent voltage-sensitive dye RH1691 and analogues thereof, Org Lett. 11(21) : 4822-4825, (2009)

2008

- Isabelle Ferezou, How many neurons for behavioral response in live animals ?, Med Sci (Paris) 24(10) : 802-804, (2008)

2007

- Elisa L. Hill, Thierry Gallopin, Isabelle Ferezou, Bruno Cauli, Jean Rossier, Paul Schweitzer and Bertrand Lambolez, Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons, J Neurophysiol 97(4) : 2580-2589, (2007)

- Thomas Berger, Aren Borgdorff, Sylvain Crochet, Florian B Neubauer, Sandrine Lefort, Bruno Fauvet, Isabelle Ferezou, Alan Carleton, Hans-Rudolf r Lüsche and Carl C. H. Petersen, Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex. , J Neurophysiol 97(5) : 3751-3762, (2007)

- Isabelle Ferezou, Elisa L. Hill, Bruno Cauli, Nathalie Gibelin, Takeshi Kaneko, Jean Rossier and Bertrand Lambolez, Extensive Overlap of µ-Opioid and Nicotinic Sensitivity in Cortical Interneurons., Cereb Cortex 17(8) : 1948-1957, (2007)

- Isabelle Ferezou, Florent Haiss, Luc J. Gentet, Rachel Aronoff, Bruno Weber and Carl C. H. Petersen, Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice, Neuron 56(5) : 907-923, (2007)

2006

- Isabelle Ferezou, Sonia Bolea and Carl C. H. Petersen, Visualising the cortical representation of whisker touch : voltage-sensitive dye imaging in freely moving mice, Neuron 50(4) : 617-629, (2006)

2002

- Isabelle Ferezou, Bruno Cauli, Elisa L. Hill, Jean Rossier, Edith Hamel and Bertrand Lambolez, 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical VIP/CCK interneurons, J Neurosci 22(17) : 7389-7397, (2002)

Books & Thesis (1)

2003

- Isabelle Ferezou, Functional characterization of a neocortical GABAergic interneuron population , In : () , (2003)

Books chapters (2)

2009

- Isabelle Ferezou, F Matyas and Carl C. H. Petersen, Imaging the brain in action - real-time voltage-sensitive dye imaging of sensorimotor cortex of awake behaving mice, In : In vivo optical imaging of brain function (Ron Frostig) CRC Press , (2009)

2007

- Sylvain Crochet, Isabelle Ferezou and Carl C. H. Petersen, Spontaneous activity in the rodent primary somatosensory cortex, In : Mechanisms of spontaneous active states in the neocortex (Igor Timofeev) Research Signpost , (2007)

Presentations (23)

2017

Isabelle Ferezou, Maria-Eugenia Vilarchao and Daniel Shulz, Global tactile information processing in the mouse somatosensory cortex at the mesoscopic scale, Talk At : NeuroFrance 2017, (Bordeaux) (2017)

2015

Isabelle Ferezou, Real time voltage sensitive dye imaging of cortical spatiotemporal dynamics evoked by tactile sensory inputs in mice, Talk At : International Workshop : Network dynamics at mesoscopic scales, (Marseille) (2015)

2013

Daniel Shulz, Maria-Eugenia Vilarchao and Isabelle Ferezou, Representation of global motion in the mouse barrel cortex, a voltage sensitive dye (VSD) imaging study, Poster At : Society for Neuroscience, (San-Diego, USA) (2013)

Daniel Shulz, Maria-Eugenia Vilarchao and Isabelle Ferezou, Direction selectivity in the mouse barrel cortex, a voltage sensitive dye (VSD) imaging study, Poster At : 11e Colloque de la Société des Neurosciences, (Lyon/Grenoble, France) (2013)

2009

Isabelle Ferezou, Florent Haiss, Luc J. Gentet, Rachel Aronoff, Bruno Weber, Jean Rossier and Carl C. H. Petersen, Voltage-sensitive dye imaging of cortical dynamics in awake mice, Talk At : 9e Colloque de la Société des Neurosciences , (Bordeaux, France) (2009)

Isabelle Ferezou, Le traitement cortical de l’information sensorielle tactile, visualisation en temps réel par imagerie sensible au potentiel chez la souris éveillée, Talk At : Congrès de Physiologie de Pharmacologie et de Thérapeutique , (Marseille, France) (2009)

2006

Isabelle Ferezou, Sonia Bolea and Carl C. H. Petersen, Visualising the cortical representation of whisker touch : voltage-sensitive dye imaging in freely moving mice, Talk At : EMBO Workshop : The Assembly and Function of Neuronal Circuits, (Ascona, Suisse) (2006)

Isabelle Ferezou, Visualising the cortical representation of touch : voltage-sensitive dye imaging of barrel cortex spatiotemporal dynamics in freely moving mice, Talk At : 2nd Swiss Meeting on Cellular & Molecular Neurobiology of Mental Diseases, (Giessbach, Suisse) (2006)

Isabelle Ferezou, Sonia Bolea, Sylvain Crochet and Carl C. H. Petersen, Voltage-sensitive dye imaging of cortical dynamics in awake mice, Poster At : Society for Neuroscience, (Atlanta GA, USA) (2006)

Isabelle Ferezou, Sonia Bolea, Sylvain Crochet and Carl C. H. Petersen, Voltage-sensitive dye imaging of cortical dynamics in awake mice., Poster At : Barrels XIX , (Atlanta GA, USA) (2006)

2005

Isabelle Ferezou, Sonia Bolea and Carl C. H. Petersen, Voltage-sensitive dye imaging of cortical spatiotemporal dynamics in freely moving mice., Poster At : USGEB-SSN-SSBP Meeting , (Zurich, Suisse) (2005)

Isabelle Ferezou, Sonia Bolea and Carl C. H. Petersen, Visualizing the cortical representation of touch : voltage-sensitive dye imaging of barrel cortex spatiotemporal dynamics in freely moving mice, Poster At : Cold Spring Harbor Meeting : Imaging Neurons & Neural Activity : new methods, new results, (Cold Spring Harbor NY, USA) (2005)

2003

Isabelle Ferezou, Elisa L. Hill, Bruno Cauli, Nathalie Gibelin, Jean Rossier and Bertrand Lambolez, Expression sélective des récepteurs opioïdes de type µ au sein d’une population d’interneurones GABAergiques néocorticaux, mise en évidence et conséquences fonctionnelles, Poster At : Société des Neurosciences, (Rouen, France) (2003)

Isabelle Ferezou, Elisa L. Hill, Bruno Cauli, Nathalie Gibelin, Jean Rossier and Bertrand Lambolez, A cellular mechanism for the involvement of µ-opioid receptor in nicotine addiction., Poster At : New Orleans, USA, (Society for Neuroscience) (2003)

Isabelle Ferezou, Extensive overlap of nicotinic and µ-opioid signaling in cortical interneurons., Talk At : International Narcotics Research Conference, (Perpignan, France) (2003)

2002

Isabelle Ferezou, Bruno Cauli, Elisa L. Hill, Jean Rossier, Edith Hamel and Bertrand Lambolez, 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical VIP/CCK interneurons, Poster At : Society for Neuroscience, (Orlando, USA) (2002)

Elisa L. Hill, C Cepeda, Isabelle Ferezou, Bruno Cauli, Jean Rossier and Bertrand Lambolez, Two subtypes of cortical excitatory neurons express the vesicular glutamate transporter VGLUT1, Poster At : Federation of European Neuroscience Societies, (Paris, France) (2002)

Bruno Cauli, Isabelle Ferezou, Elisa L. Hill, Jean Rossier and Bertrand Lambolez, D-Ala2,N-MePhe4,Gly5-ol-enkephalin (DAMGO), a µ-opioid receptor agonist, selectively inhibits a subset of neocortical interneurons expressing vasoactive intestinal peptide (VIP), Poster At : Federation of European Neuroscience Societies, (Paris, France) (2002)

Isabelle Ferezou, Bruno Cauli, Elisa L. Hill, Jean Rossier, Edith Hamel and Bertrand Lambolez, Serotonergic synaptic excitation of neocortical VIP/CCK interneurons mediated by 5–HT3 receptors., Poster At : Federation of European Neuroscience Societies, (Paris, France) (2002)

Elisa L. Hill, C Cepeda, Isabelle Ferezou, Bruno Cauli, Jean Rossier and Bertrand Lambolez, Two subtypes of cortical excitatory neurons express the vesicular glutamate transporter VGLUT1, Poster At : Society for Neuroscience, (Orlando, USA) (2002)

2001

Bruno Cauli, Isabelle Ferezou, Jean Rossier and Bertrand Lambolez, Selective excitation by 5–HT3 receptors of subtypes of interneurons in the rat neocortex., Poster At : Society for Neuroscience, (San-Diego, USA ) (2001)

Isabelle Ferezou, Bruno Cauli, Jean Rossier and Bertrand Lambolez, D-Ala2,N-MePhe4,Gly5-ol-enkephalin (DAMGO), a µ-opioid receptor agonist, selectively inhibits a subset of neocortical interneurons, Poster At : Society for Neuroscience, (San-Diego, USA) (2001)

2000

Isabelle Ferezou, H Axelrad, Jeanne Lainé, M.E Marc, W.E O’Brien and W Wiesinger, Localisation cellulaire de l’argininosuccinate synthétase (ASS) dans le cortex cérébelleux de rat, Poster At : Société des Neurosciences , (Toulouse, France) (2000)


  Webmaster Plan du site Planning Crédits
Syndication RSS  
  Format Mobiles
 
Administration
Cog-Comp Dev-Evo Mol-Circ ICN