Le cerveau multidimensionnel

Accueil du site Neuro-PSI > Infos_des_départements > Travailler à Neuro-PSI

3 POSTDOC positions at UNIC

1- Postdoc or Engineer position : Multi-dimensional data visualization.

 

The BRAINSCOPES program funded by the Paris-Saclay University is looking for a talented scientist to work in a collaborative project supervised by Thomas Deneux of the CNRS Unit for Neurosciences, Information and Complexity, (UNIC). Modern neurophysiology recordings generate large amount of data, requiring both sophisticated preprocessing and analysis techniques and powerful visualization tools that allow a flexible and intuitive exploration of the data’ structure. The UNIC laboratory has started to develop a visualization program, XPLOR, which offers a smooth navigation and fast extraction of meaningful information across multiple data dimensions. Although it is currently used for neurophysiological imaging (see ref. [1,2]), this program is generic and has a potential for applications beyond this field.

The position will aim at further developing this program :
- consolidating the existing functionalities by translating XPLOR from Matlab to Python (or C++),
- adding pattern recognition (e.g. clustering), machine learning methods (regression models, SVM classification, possibly deep learning methods) to extract regularities in the data.
The work will involve collaborations with different teams of the Paris-Saclay Institute of Neuroscience who will use the software, and further diffusion through publications, conferences, collaborative code sharing.
The position is immediately available for one year, potentially renewable and is open to candidates with strong skills in programming and machine learning having interest for neurobiology research.

To apply, please contact Thomas Deneux.

- PDF

 

References :
[1] Deneux et al. Accurate spike estimation from noisy calcium signals for ultrafast three-dimensional imaging of large neuronal populations in vivo. Nature Communication 2016.
[2] Deneux, Kempf et al. Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities. Nature Communication 2016.

 


2- Endoscopy in freely behaving mice.

The BRAINSCOPES program funded by the Paris-Saclay university is looking for a talented scientist to work in a collaborative project run by the laboratories of Brice Bathellier and Gilles Fortin, involving microendoscopic one- and two-photon imaging in deep brain areas.
The project aims to study, in mice, the neuronal population dynamics of genetically identified cell types in brainstem nuclei involved in early auditory processing and in the control of respiratory and locomotor behaviours. In this context, the recruited postdoctoral scientist will be responsible for :

- implementing the insertion of chronic endoscopic lenses according to readily published protocols

- imaging neuronal activity of GCAMP6-labelled neurons using either an Inscopix head-mounted microscope (freely moving conditions), or a two-photon microscope (head-fixed) during complex auditory stimulations and various exploratory behaviours and metabolic conditions.

The project will be run within the novel Paris-Saclay Institute of Neuroscience (NeuroPSI) and the Unit for Neuroscience Information and Complexity (UNIC) located in Gif sur Yvette, 45 min from Paris centre.
The position is available for one year, potentially renewable and is open to candidates with an experimental background (e.g. PhD in Neurophysiology) and motivation to interface with new imaging technologies and cutting edge data analysis techniques. Prior experience with in vivo manipulations of the rodent brain and/or optical imaging is also desirable.

To apply, please contact Brice Bathellier or Julien Bouvier with a CV and contact details of two references.

- PDF

 

Related publications :

Deneux T, Kempf A, Daret A, Ponsot E, Bathellier B. Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities. Nature Communications, 2016, 7, 12682.

Bouvier J, Caggiano V, Leiras R, Caldeira V, Bellardita C, Balueva K, Fuchs A, Kiehn O. Descending Command Neurons in the Brainstem that Halt Locomotion. Cell 2015, 19 ;163(5):1191-203.

Ruffault PL, D’Autréaux F, Hayes JA, Nomaksteinsky M, Autran S, Fujiyama T, Hoshino M, Hägglund M, Kiehn O, Brunet JF, Fortin G, Goridis C (2015). The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂. Elife. 2015 Apr 13 ;4.

Talpalar A, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O. Dual mode operation of neuronal networks involved in left-right alternation. Nature, 2013, Aug 1 ;500(7460):85-8.

Bathellier B, Ushakova L, and Rumpel S, Spontaneous association of sounds by discrete neuronal activity patterns in the neocortex. Neuron, 2012, 76(2):435-49.

 


3- Two-photon calcium imaging and auditory processing.

The Bathellier lab combines state-of-the-art two-photon microscopy, optogenetics and behaviour together with computational modelling to investigate the principles of auditory processing in mice (e.g. Deneux et al. 2016, Bathellier et al. 2012). In the context of a new project, founded for three years, we are searching for a talented researcher to perform two-photon calcium imaging of neurons (>1000 cells simultaneously) and axon terminals across the auditory system combined with optogenetic silencing of specific auditory areas during perception of complex, temporally modulated sounds. These experiments will be combined with high throughput data processing methods already developed in the lab as well as multilayer neuronal network modelling to extract generic computational architectures explaining sound representations in the mouse brain.

The Bathellier lab is part of the CNRS Unit for Neuroscience Information and Complexity (UNIC), a department of the new Paris-Saclay Institute of Neuroscience (NeuroPSI), with long standing expertise in interdisciplinary approaches to sensory neuroscience. It is located in Gif sur Yvette, 45 min from Paris center on the campus of the Paris-Saclay university.

The position is open to candidates to with a strong experimental background (PhD in Neurophysiology) and motivation to interface with modelling approaches, or to candidates with a PhD in physics, maths, or computational neuroscience but willing to acquire practical expertise in experimental neurophysiology.

To apply, please contact Brice Bathellier with a CV and contact details of two references.

- PDF

 

- Deneux T, Kempf A, Daret A, Ponsot E, Bathellier B, Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities. Nature Communications, 2016, 7, 12682.
- Bathellier B, Ushakova L, and Rumpel S, Spontaneous association of sounds by discrete neuronal activity patterns in the neocortex. Neuron, 2012, 76(2):435-49.


  Webmaster Plan du site Planning Crédits
Syndication RSS  
  Format Mobiles
  Dev-Evo Cog-Comp Mol-Circ