Two-photon calcium imaging and auditory processing.
The Bathellier lab combines state-of-the-art two-photon microscopy, optogenetics and behaviour together with computational modelling to investigate the principles of auditory processing in mice (e.g. Deneux et al. 2016, Bathellier et al. 2012). In the context of a new project, founded for three years, we are searching for a talented researcher to perform two-photon calcium imaging of neurons (>1000 cells simultaneously) and axon terminals across the auditory system combined with optogenetic silencing of specific auditory areas during perception of complex, temporally modulated sounds. These experiments will be combined with high throughput data processing methods already developed in the lab as well as multilayer neuronal network modelling to extract generic computational architectures explaining sound representations in the mouse brain.
The Bathellier lab is part of the CNRS Unit for Neuroscience Information and Complexity (UNIC), a department of the new Paris-Saclay Institute of Neuroscience (NeuroPSI), with long standing expertise in interdisciplinary approaches to sensory neuroscience. It is located in Gif sur Yvette, 45 min from Paris center on the campus of the Paris-Saclay university.
The position is open to candidates to with a strong experimental background (PhD in Neurophysiology) and motivation to interface with modelling approaches, or to candidates with a PhD in physics, maths, or computational neuroscience but willing to acquire practical expertise in experimental neurophysiology.
To apply, please contact Brice Bathellier with a CV and contact details of two references.
Deneux T, Kempf A, Daret A, Ponsot E, Bathellier B, Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities. Nature Communications, 2016, 7, 12682.
Bathellier B, Ushakova L, and Rumpel S, Spontaneous association of sounds by discrete neuronal activity patterns in the neocortex. Neuron, 2012, 76(2):435-49.