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Vendredi de Neuro-PSI le 30 mars 2018

Vendredi 30 mars à 11h00, en salle de conférences AlFred Fessard, bâtiment 32, CNRS Gif-sur-Yvette, Jean-Pierre Levraud de l’Institut Pasteur, Paris / CNRS UMR3738, Département Biologie du Développement et Cellules Souches, Unité Macrophages et Développement de l’Immunité- Groupe Réponse à l’Infection Dans l’Organisme Entier, présente un exposé intitulé
« Imaging host-pathogen interaction in zebrafish - all roads lead to neuroinflammation »

- research.pasteur.fr/en/team/

Invité par Jean-Stéphane Joly

- Voir le pdf


I am an immunologist with an evolutionary outlook. After graduating from Ecole Polytechnique, I did my PhD on tumor-infiltrating cytotoxic T cells, using mice. I moved to Dictyostelium for my post-doc, and finally chose zebrafish as my main model of study.

I am particularly interested in “regionalized immunity” : how local innate immune responses counteract the propagation of pathogens. For this, I developed models of infection in zebrafish larvae. I will present a few examples of how we can simultaneously image the distribution of the microbe and the immune response, at the whole-body to the subcellular scales.

Recently, I focused on infections with alphaviruses : Chikungunya and Sindbis viruses. We showed that both cross the blood-brain barrier ; surprisingly, while one relies on endothelium infection, the other prefers axonal transport. A potent interferon response mediated by neutrophils soon wipes the virus from the periphery, leaving a persistent infection of the central nervous system (CNS). This constitutes a powerful model of neonatal viral encephalitis.
My project is now to fully characterize the local immune response, notably the repertoire of interferon stimulated genes specifically expressed by the different CNS cell types, using a comparative approach in mice and zebrafish. Beyond the role of these genes in virus restriction and in deleterious side effects of neuroinflammation, I want to test their contribution to the repair mechanisms activated after resolution of infection. The long-term goal would be to reduce the neurological sequelae of infectious meningo-encephalitis.


  • Vendredi 30 mars 11:00-12:30 - Jean-Pierre Levraud - Institut Pasteur, Paris / CNRS UMR3738 Département Biologie du Développement et Cellules Souches

    Imaging host-pathogen interaction in zebrafish - all roads lead to neuroinflammation

    Résumé : Invité par Jean-Stéphane Joly

    Lieu : Salle de Conférences Alfreed Fessard - Bâtiment 32 CNRS DR4, 1, avenue de la Terrasse Gif-sur-Yvette

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