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Neuro-PSI Conference on February 2nd

On Friday, February 2nd at 11:00, Sepand Rastegar from the Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Germany will give a talk on this following topic
« Id1 : a key player in the maintenance of the neural stem cell pool during adult neurogenesis and regeneration in the zebrafish telencephalon. »

- www.itg.kit.edu/

Invited by Jean-Stéphane Joly

- See the pdf

Abstract :
Neurons are the building blocks of all nervous systems. In mammals, neurons are usually not replaced when damaged or dead, which can result in progressive degeneration and death of neural tissues, causing for instance ataxias or dementias.
By contrast, teleost fish have the remarkable ability to generate new neurons and to repair injuries even during adult life. Therefore, we use zebrafish as a model to understand when, where and how adult neurogenesis works in these fish and how it differs from the situation in mammals.
In a genome-wide screen for regulators of transcription expressed in the adult zebrafish brain and their response to injury, we found the inhibitor of differentiation 1 (id1) gene to be unregulated in response to injury. Its expression was mapped to quiescent type I neural stem cells in the adult telencephalic ventricular zone stem cell niche. Gain and loss of Id1 function in vivo demonstrated that it promotes stem cell quiescence and that it possibly acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals.
We are currently exploring which signaling pathways control expression of id1 during constitutive and induced neurogenesis in adult zebrafish, and I will present recent preliminary results on the transcriptional regulation of id1 in the seminar.


CV Rastegar, Sepand, Ph.D.

Research interest

Characterization of molecular mechanisms that regulate zebrafish embryonic and adult neurogenesis with a focus on regulation of transcription.
Professional experience and education

  • Senior researcher at the Institute of Toxicology and Genetics,
  • Karlsruhe Institute of Technology, Germany
  • Research Associate (CR1, INSERM), IGBMC, Strasbourg, France
  • Postdoctoral Fellow at IGBMC, Strasbourg, France
  • Ph.D., Department of Biochemistry, Ulm, Germany
  • Master and diploma, University of Strasbourg, France


Selected publications

- Diotel N, Beil T, Strähle U, and Rastegar S. Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Gene Expr Patterns. 2015 Sep-Nov ; 19 (1-2):1-13. doi : 10.1016/j.gep.2015.05.004.

- Diotel N, Rodriguez Viales R, Armant O, März M, Ferg M, Rastegar S, Strähle U. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. J Comp Neurol. 2015 Jun 1 ;523(8):1202-21. doi : 10.1002/cne.23733.

- Naville M, Ishibashi M, Ferg M, Bengani H, Rinkwitz S, Krecsmarik M, Hawkins T, Wilson S, Manning E, Chilamakuri C, Wilson D, Louis A, Raymond F, Rastegar S, Strähle U, Lenhard Boris ,Bally-Cuif L, Van Heyningen V, Fitzpatrick D, Becker T, and Roest Crollius. H. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. Nat Commun. 2015 Apr 24 ; 6 : 6904. doi : 10.1038/ncomms7904.

- Rodriguez Viales R, Diotel N, Ferg M, Armant O, Eich J, Alunni A, März M, Bally-Cuif L, Rastegar S, Strähle U. The helix-loop-helix protein id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Stem Cells. 2015 Mar ; 33(3):892-903. doi : 10.1002/stem.1883.

- Schmidt R, Beil T, Strähle U, Rastegar S. Stab wound injury of the zebrafish adult telencephalon : a method to investigate vertebrate brain neurogenesis and regeneration. J Vis Exp. 2014 Aug 4 ; (90):e51753.

- Armant O, März M, Schmidt R, Ferg M, Diotel N, Ertzer R, Bryne JC, Yang L, Baader I, Reischl M, Legradi J, Mikut R, Stemple D, van IJcken W, van der Sloot A, Lenhard B, Strähle U, Rastegar S. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Dev.Biol. 2013 380(2):351-62.

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