Le cerveau multidimensionnel

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We develop original methodologies and tools for the in vivo multiscale and multimodal observation, quantification and multilevel theoretical modelling of biological processes. Our strategies are the basis for the predictive understanding of the morphogenesis of living organisms in normal and pathological conditions and open the way to new kind of pharmacology and toxicology screening schemes.

In this context we foresee the following missions :

  • anticipating the needs of integrative cell biology and developmental biology in terms of methods and tools
  • tackling challenging biological issues as proof of concept,
  • proposing collaborative services through an innovative platform for imaging, image processing and multilevel modeling
  • fostering the expansion of a transdisciplinary community through the e-Laboratory Embryome-DC in the context of the Complex Systems UNESCO UNITWIN Complex Systems-DC.

Multilevel Dynamics in Morphogenesis
Gif-sur-Yvette, France

Director :
Nadine Peyriéras, Director/DR2-CNRS
Started the team in 2005
The BioEmergences Website


A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation.
Delile J, Herrmann M, Peyriéras N, Doursat R.
Nat Commun. 2017 Jan 23 ;8:13929. doi : 10.1038/ncomms13929.

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Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction.
Dyballa S, Savy T, Germann P, Mikula K, Remesikova M, Špir R, Zecca A, Peyriéras N, Pujades C
Elife. 2017 Jan 4 ;6. pii : e22268. doi : 10.7554/eLife.22268.

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A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage.
Faure E, Savy T, Rizzi B, Melani C, Stašová O, Fabrèges D, Špir R, Hammons M, Čúnderlík 6, Recher G, Lombardot B, Duloquin L, Colin I, Kollár J, Desnoulez S, Affaticati P, Maury B, Boyreau A, Nief JY, Calvat P, Vernier P, Frain M, Lutfalla G, Kergosien Y, Suret P, Remešíková M, Doursat R, Sarti A, Mikula K, Peyriéras N, Bourgine P.
Nat Commun. 2016 Feb 25 ;7:8674. doi : 10.1038/ncomms9674

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Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis.
Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E.
Nat Commun. 2016 Apr 18 ;7:11288. doi : 10.1038/ncomms11288.

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A digital framework to build, visualize and analyze a gene expression atlas with cellular resolution in zebrafish early embryogenesis.
Castro-González C, Luengo-Oroz MA, Duloquin L, Savy T, Rizzi B, Desnoulez S, Doursat R, Kergosien YL, Ledesma-Carbayo MJ, Bourgine P, Peyriéras N, Santos A.
PLoS Comput Biol. 2014 Jun 19 ;10(6):e1003670. doi : 10.1371/journal.pcbi.1003670. eCollection 2014.

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The Bcl-2 homolog Nrz inhibits binding of IP3 to its receptor to control calcium signaling during zebrafish epiboly.
Bonneau B1, Nougarède A, Prudent J, Popgeorgiev N, Peyriéras N, Rimokh R, Gillet G.
Sci Signal. 2014 Feb 11 ;7(312):ra14. doi : 10.1126/scisignal.2004480.

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Inhibitory signalling to the Arp2/3 complex steers cell migration.
Dang I1, Gorelik R, Sousa-Blin C, Derivery E, Guérin C, Linkner J, Nemethova M, Dumortier JG, Giger FA, Chipysheva TA, Ermilova VD, Vacher S, Campanacci V, Herrada I, Planson AG, Fetics S, Henriot V, David V, Oguievetskaia K, Lakisic G, Pierre F, Steffen A, Boyreau A, Peyriéras N, Rottner K, Zinn-Justin S, Cherfils J, Bièche I, Alexandrova AY, David NB, Small JV, Faix J, Blanchoin L, Gautreau A.
Nature. 2013 Nov 14 ;503(7475):281-4. doi : 10.1038/nature12611. Epub 2013 Oct 16.

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