The Multidimensional Brain

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Personal Background

Jean-Stéphane JOLY (DR2 - INRA) Team leader ; 

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  • Alumnus from INAPG
  • Agronomy enginer (Agro Paris Tech)
  • PhD from Institut Pasteur in Francois Jacob’s lab on zebrafish gastrulation.
  • Recruited in INRA of Jouy-en-Josas working on medaka nervous system development.

Leading MSNC team since 2000 together with Franck Bourrat. I have managed 3 EU projects. I have founded AMAGEN facility in the EFOR network focused on laboratory model species.


Franck BOURRAT (CR1 - INSERM) ; 

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  • Alumnus from ENS Ulm, Paris
  • PhD on the development of the rat precerebellar system
  • Research team founded with Daniel Chourrout, on the INRA campus of Jouy-en-Josas, on mechanisms controlling cell proliferation in the developing medaka CNS..

My interest lies in the transcriptional mecanisms of development cell cycle exit (proliferation arrest), with an emphasis on comparative (evolutionary) aspects. My aim is to take advantage of cellular conveyor belts models to unravel mechanisms regulating developmental cell cycle exit in Metazoans, and study their conservation.


Françoise JAMEN (Assistant professor University Paris-Sud) ; 

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  • Alumnus from ENS of Lyon.
  • PhD in Montpellier: Transcriptional regulation and function of PACAP receptor (PAC1) in mouse.
  • Post-doc at UCL, London, in William Richardson’s lab on the study of the oligodendrocyte progenitors in the mouse brain.

My research focus on the study of the roles of ribosome biogenesis factors in neural progenitors and neural stem cells in zebrafish embryo.


Jean-Michel HERMEL (IR1 CNRS) ; 

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  • Thèse effectuée à Gif-sur-Yvette dans le laboratoire de Ladislav Tauc. Étude pharmacologique et électrophysiologique de la fasciculine
  • Post-doc à Yale sur la caractérisation cellulaire et biochimique de ICA512, un autoantigène impliqué dans le diabète de type 2.
  • Recruté au CNRS dans le laboratoire de Philippe Hantraye. Étude biochimique de modèles de la maladie de Huntington chez le rat et le singe.
  • PhD from INAF CNRS Gif-sur-Yvette: Pharmacological and electrophysiological study of fasciculine on neuromuscular junction in Ladislav Tauc lab.
  • Post-doctoral Associate : Cellular and biochemical characterisation of ICA512, a new autoantigen involved in type 2 diabetis.
    Yale, Michele Solimena and Pietro de Camilli labs.
  • Biochemical study of Huntington disease models in rat and monkey. Philippe Hantraye lab.

Morphology and ultrastructure of the OT, of the nucleolus and of neuroepithelial stem cells during brain development in zebrafish and medaka.


Aurélie HEUZE (IE CNRS PhD student) : Master 2 « Cellular and Tissue Engineering » (Caen University) ; 

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I study the diversity of progenitor and differentiated cells of the optic tectum and the regenerative capacity of this organ in zebrafish by performing chemical ablations. I am also lab manager of the team.


Matthieu SIMON (TR INRA) : Research Tech INRA Master 2 GCDE (Paris-Sud University) ; 

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I work on the regulatory logic of stem cells midbrain. I make particular dissection of regulatory sequences I also oversee the management of fish lines for the team and for infrastructure Tefor.


Stéphanie BOUFFARD (PhD student) ; 

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My project concerns the study of genes coding for ribosome biogenesis factors and their function in the biology of neural progenitors in optic tectum in zebrafish embryo.


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