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Conférence Neurospin


Lundi 24 septembre 2018 - 11h00, Amphi NeuroSpin
Centre d’études de Saclay

« Big Data driven research in schizophrenia : focus on white matter »

Peter KOCHUNOV - Université du Maryland, Psychiatric Research Center



Lundi 24 septembre 2018 - 14h00, Amphi NeuroSpin
Centre d’études de Saclay

« An imaging-genetic study of the asymmetries in the temporal lobe structures: association of these human-specific markers of development with genetics »

PhD Defence
Yann Le Guen (NeuroSpin / UNATI)

Abstract :
The asymmetrical structure of the temporal lobe has already been demonstrated. These structural asymmetries are often assumed to contribute to the human language lateralization. One noticeable asymmetry is the one of the superior temporal sulcus (STS) depth observed from birth in humans, but not in chimpanzee. In this thesis, we were interested in the genetic roots underlying this asymmetry. To this aim, we used automated extraction method of asymmetrical structures such as the sulcal roots or transverse gyri, so called plis de passage. First, we reproduced the STS rightward depth asymmetry in two large cohorts (HCP and UK Biobank) and we demonstrated that the left STS is more often interrupted by a transverse gyrus than its counterpart. Second, the heritability estimates of depth/convexity of sulcal roots in the STS and of plis de passages are higher in the left hemisphere.

This suggests asymmetric genetic cues contributing to the formation of these asymmetrical structures in the temporal lobe. In addition, we have shown that the functional activations in the angular gyrus have a significant shared genetic variance with the human cognitive performance. Finally, we have identified a cis-regulating region of the KCNK2 gene, as being significantly associated with the width and cortical thickness of the brain sulci, which are features of brain ageing.



  • Monday 24 September 11:00-12:30 - Peter KOCHUNOV - Université du Maryland, Psychiatric Research Center

    Big Data driven research in schizophrenia: focus on white matter

    Résumé : Conférence Neurospin

    Lieu : Neurospin - Bâtiment 145, CEA Gif-sur-Yvette

    Notes de dernières minutes :

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