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Stem Cells and Neurogenesis in the Retina (SCaNR) - Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)

Group leader : Muriel Perron

Our SCaNR research group is associated with the private laboratory of Retina France association, the CERTO (Centre d’Etudes et de Recherches Thérapeutiques en Ophtalmologie), with whom we are developing our research projects in collaboration.

Our long-term goal is to provide foundations for the development of innovative therapeutic approaches in patients afflicted with degenerative retinal diseases, such as Retinitis Pigmentosa (RP) or Aged Macular Degeneration (AMD).

One of the intended strategy is to revitalize the naturally limited regenerative capacity of the mammalian retina. In fish and amphibians , different populations of stem cells contribute efficiently to the regeneration of the retina following injury. These animals thus offers powerful model system to dissect the signaling pathways underlying regeneration and provide essential information to stimulate the proliferation and neurogenic potential of dormant retinal stem cells in mammals. In this context, we study and compare in both Xenopus and mouse, two models with very different regenerative capacities, the mechanisms underlying the maintenance, recruitment and activity of adult retinal stem cells in neural tissue homeostasis and regeneration.

Neuroprotection represents another promising avenue for potential therapeutic approaches to treat retinal degenerative diseases. We are thus developing another axis of research dedicated to the study of the molecular mechanisms and signalling pathways underlying photoreceptor survival.

Our team is affiliated to the GDR "Stem Cells in vivo".


 

News 2017

 

Read our recent manuscript revealing that Müller glial cells are able to reenter into the cell cycle and regenerate photoreceptor cells in the Xenopus retina

 

 

Read our recent manuscript revealing a link between reactive gliosis in Müller cells and the Hippo/YAP pathway

 

News 2016

Read our review on Müller cells and their regenerative ability in different species

 

 

 

 

 

 

News 2015

Read our article in eLife

 

 

 

 

 

 

See the post in The Node

 


 

How to reach us :

Take the RER B and stop at Orsay Ville station
Follow the black arrow on the map towards the building 440-447
(about 10 min walk).
We are on the first floor of the building.

SCaNR / CERTO
Bâtiment 445 Rue Claude Bernard
Université Paris-Sud
91405 Orsay cedex. France


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