Our SCaNR research group is associated with the private laboratory of Retina France association, the CERTO (Centre d’Etudes et de Recherches Thérapeutiques en Ophtalmologie ; Center of Therapeutic Studies and Research in Ophthalmology), with whom we are developing our research projects in collaboration.
Our long-term goal is to provide foundations for the development of innovative therapeutic approaches in patients afflicted with degenerative retinal diseases, such as Retinitis Pigmentosa (RP) or Aged Macular Degeneration (AMD).
One of the intended strategy is to revitalize the naturally limited regenerative capacity of the mammalian retina. In fish and amphibians , different populations of stem cells contribute efficiently to the regeneration of the retina following injury. These animals thus offers powerful model system to dissect the signaling pathways underlying regeneration and provide essential information to stimulate the proliferation and neurogenic potential of dormant retinal stem cells in mammals. In this context, we study and compare in both Xenopus and mouse, two models with very different regenerative capacities, the mechanisms underlying the maintenance, recruitment and activity of adult retinal stem cells in neural tissue homeostasis and regeneration.
Neuroprotection represents another promising avenue for potential therapeutic approaches to treat retinal degenerative diseases. We are thus developing another axis of research dedicated to the study of the molecular mechanisms and signalling pathways underlying photoreceptor survival.
Read our recent review on Müller cells and their regenerative ability in different species
- Müller glial cell-dependent regeneration of the neural retina : An overview across vertebrate model systems (2016). Annaïg Hamon, Jérôme E. Roger, Xian-Jie Yang and Muriel Perron. Developmental Dynamics published online : 8 JAN 2016 DOI : 10.1002/dvdy.24375.
Read our article in eLife
- YAP controls retinal stem cell DNA replication timing and genomic stability. (2015). Cabochette P*, Vega-Lopez G*, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O§, Perron M§. eLife 4:e08488.
See the post in The Node
- The Node on October 7th, 2015
How to reach us :
Take the RER B and stop at Orsay Ville station
Follow the black arrow on the map towards the building 440-447
(about 10 min walk).
We are on the first floor of the building.
SCaNR / CERTO
Bâtiment 445 Rue Claude Bernard
91405 Orsay cedex. France