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TEFOR

The TEFOR infrastructure supports research on two alternative model species :
zebrafish and drosophila.
TEFOR is a distributed infrastructure composed of eleven partners. It is funded by a “Grand Emprunt Investissements d’Avenir” ANR grant.
We are looking for research program collaborators on genome editing in three species rat (TRANSGENESIS NANTES), zebrafish (AMAGEN) and drosophila (FLY ACILITY).

 

MAJOR AIMS
The major aims of the TEFOR infrastructure are :
- to provide transgenesis, mutagenesis, and phenotyping services and collaborative research projects in drosophila and zebrafish.
- to generate in both species new collections of transgenic lines.
- to develop technology projects in the areas of genome rewriting, viewing of 3D images and database archiving.

 

GENOME EDITING TRANSGENESIS RESEARCH COLLABORATION
TALE-nuclesases (Transcription Activator Like Effector nucleases) and Cas9 endonucleases are at the basis of novel strategies for genome editing. They have been shown to work in a wide variety of model and non model organisms.

 

Recent publications :

 

High-resolution 3D imaging of whole organ after clearing : taking a new look at the zebrafish testis.
Frétaud M, Rivière L, De Job É, Gay S, Lareyre JJ, Joly JS, Affaticati P, Thermes V
Sci Rep. 2017 Feb 17 ;7:43012. PMID : 26923600

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Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.
Passoni G, Langevin C, Palha N, Mounce BC, Briolat V, Affaticati P, De Job E, Joly JS, Vignuzzi M, Saleh MC, Herbomel P, Boudinot P, Levraud JP
Dis Model Mech. 2017 Jul 1 ;10(7):847-857. PMID : 28483796

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- TEFOR Core Facility

 

 

 

 

 

 

 

 

Elodie Dejob & Pierre Affaticati


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